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hypertension
Mental health

Hypertension medications may be used to slow ageing process: Research

by Pragati Singh
written by Pragati Singh

Researchers discovered that the drug rilmenidine can increase life expectancy and halt the ageing process. The findings, published in Aging Cell, reveal that treating animals with rilmenidine, a drug currently used to treat hypertension, at young and elderly ages enhances lifespan and improves health indices, mirroring the effects of calorie restriction. They also show that the I1-imidazoline receptor nish-1 mediates the healthspan and lifespan effects of rilmenidine administration in the roundworm C. elegans, indicating this receptor as a potential longevity target.

Unlike other medications previously evaluated for this purpose by the researchers, the frequently prescribed, oral antihypertensive rilmenidine offers the potential for future human translatability due to uncommon and non-severe adverse effects. To date, the most effective anti-aging intervention, enhancing longevity across animals, has been a calorie restriction diet. However, human studies of calorie restriction have had inconsistent outcomes and adverse effects, implying that developing drugs like rilmenidine that can replicate the benefits of caloric restriction is the most logical anti-aging technique.

Professor Joao Pedro Magalhaes, who led the research whilst at the University of Liverpool and is now based at the University of Birmingham, said: “With a global ageing population, the benefits of delaying ageing, even if slightly, are immense. Repurposing drugs capable of extending lifespan and healthspan has a huge untapped potential in translational geroscience. For the first time, we have been able to show in animals that rilmenidine can increase lifespan. We are now keen to explore if rilmenidine may have other clinical applications.”

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Mental health

Do oral bacteria play any role in hypertension?

by Vaishali Sharma
written by Vaishali Sharma

The microbiota and hypertension
Blood pressure is the force exerted by blood against the artery walls. Blood pressure naturally rises and falls during the day, but if it remains high, it can create health problems.

A person with hypertension is more likely to have a stroke or develop heart disease, according to the Centers for Disease Control and Prevention (CDC). Hypertension affects an estimated 47 percent of individuals in the United States, with the ailment impacting older persons and women the most.

Despite the fact that there are evidence-based treatments to avoiding and lowering hypertension, it is nevertheless quite common, according to researchersTrusted Source. As a result, research into why people acquire hypertension and how to treat it is still ongoing. The association between the microbiota and hypertension risk is worth additional examination, according to scientists at Trusted Source. The microbiome is a collection of microbes — primarily bacteria — that live in and on a person’s body. Scientists are finding more and more evidence that the microbiome plays a role in maintaining good health.

There is some evidenceTrusted Source that the gut microbiome affects an individual’s risk of hypertension. In the present study, however, the researchers focused on the oral microbiome and its relationship with hypertension risk.

Over 1,000 people took part in the event. The Buffalo Osteoporosis and Periodontal Disease Study was used by the researchers. They analysed data from 1,215 women who had gone through menopause and were 63 years old on average when they entered in the research between 1997 and 2001. The researchers obtained samples of the individuals’ oral microorganisms from below their gumline and tested their blood pressure when they signed up. The researchers also obtained the individuals’ medical histories and a list of any drugs they were currently taking.

At the start of the trial, 40% of the patients were on blood pressure medication.

During the 10-year average follow-up, around half of the people who did not have hypertension or were not getting treatment for the illness at baseline received a hypertension diagnosis and therapy.

Bacteria and hypertension are linked.
The researchers discovered ten species of oral bacteria that were connected to a higher risk of hypertension, ranging from a 10% to a 16 percent increase, after studying the oral bacteria samples.

Five bacteria were also linked to a 9–18 percent decreased incidence of hypertension, according to the study.

With the exception of two bacteria, the researchers’ findings were consistent even after accounting for age and other confounding lifestyle and clinical variables.

Bacteria and hypertension are linked.
Prof. LaMonte said, “We also know that oral bacteria may escape from the mouth and travel through the bloodstream to other regions of the body.”

“Oral bacteria have been discovered within the artery wall encased in atherosclerotic plaques, for example.” Atherosclerosis causes artery hardening, which causes blood pressure to rise. As a result, it’s probable that oral bacteria and arterial atherosclerosis are linked.”

“Of course, there’s always the chance that ours was a lucky find. “It will be crucial to see if other research looking at this topic come up with similar or different conclusions,” Prof. LaMonte added.

The American Dental Association (ADA) also talked with MNT, emphasising that a correlation between certain mouth bacteria and hypertension does not always suggest causality.

“An association between two items does not imply that one causes the other. This study does not give information on whether controlling microbes affects a person’s chance of acquiring hypertension.”

“It does imply, however, that if a person gets hypertension and begins taking blood pressure medication, there may be a change in bacteria in the oral microbiome.”

People should do the following to maintain a healthy oral microbiota, according to the ADA:

Brush their teeth twice a day with fluoride toothpaste and floss at least once a dayeat a healthy diet that limits sugary beverages and snack consult a dentist regularly for prevention and treatment of oral disease

To determine causation, researchers would need to conduct a randomized clinical trial.

According to Prof. LaMonte, “At present, we are not planning a randomized clinical trial to further evaluate this hypothesis, but such a trial will be critical to know whether or not our results reflect causation or merely association.”

 

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epilepsy
Mental health

Know what secondary hypertension is and who is at risk

by Pragati Singh
written by Pragati Singh

Everything you should know about secondary hypertension

Despite the fact that high blood pressure, often known as hypertension, is a common health problem in India, over 70% of cases go undetected. One of the reasons is a lack of knowledge about the causes and risk factors, especially among the rural population, which leads to low treatment rates and predisposes people to life-threatening illnesses. Many people are unaware that there are two kinds of hypertension: primary and secondary hypertension. The most frequent type of hypertension is primary hypertension, which is caused by bad lifestyle behaviours or a family history of hypertension, while secondary hypertension is usually caused by other medical issues. It accounts for around 10% of all cases of high blood pressure and is frequently misdiagnosed.

Secondary hypertension: A Basic Guide

A higher than normal amount of pressure in your blood vessels defines high blood pressure. A systolic and diastolic number on a blood pressure monitoring system is used to assess it.

Secondary hypertension develops as a result of a long-term illness or condition. Primary hypertension differs in several ways from this type of hypertension. Secondary hypertension can be treated effectively to help control the underlying health condition and reduce the risk of health problems.

Secondary hypertension symptoms

Secondary hypertension, like main hypertension, displays modest symptoms. Even if it reaches a dangerous level, if one is not vigilant, it is difficult to recognise. These typical indicators indicate that you have secondary hypertension if you have been diagnosed with high blood pressure:
A condition that is uncontrollable despite the use of blood pressure medicines

Secondary hypertension is caused by a variety of factors.

A number of chronic diseases might cause your blood pressure to rise. High blood pressure management can also assist to alleviate the symptoms of various underlying health problems. The following are some of the causes of secondary hypertension:

Diabetes: If left untreated, diabetes can put an undue strain on the kidneys’ ability to remove sugar from the bloodstream. This disorder can cause blood pressure to rise over time.

Polycystic kidney disease: Cysts in the kidneys can hinder normal renal function, resulting in a rise in blood pressure.

Renovascular hypertension is a type of high blood pressure induced by narrowing of the arteries leading to the kidneys.

Cushing syndrome: Long-term high cortisol levels can cause Cushing syndrome.

Treatment

To treat hypertension, the underlying problem that causes high blood pressure must be addressed first. The blood pressure will return to normal after the underlying issue is treated. The doctor will prescribe medication, lifestyle adjustments, and other treatment methods to lower your blood pressure level, depending on your situation.

 

 

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