An effective drug have been found by the researchers of US which can prevent tumour from growing.
University of colorado Cancer Center’s team have found that slowing down NLRP3 can help in reducing inflammation and curb tumour growth and proggrssion.
Carlo Marchetti, from the varsity’s School of medicine, said “NLRP3 is a member of a larger family that is involved in sensing danger signals”.
” It is a receptor that surveils that intercellular compartment of a cell, looking for danger molecules or pathogens.
Marchetti said “When NLRP3 recognises these signals, it leads to the activation of caspase-1, a protein involved in the processing and maturation of interleukin-1-beta into it’s biological active form, causing an intense inflammatory response. We found that in melanoma, this process is dyseregulated, resulting in tumour growth”.
The study is published in the journal PNAS.
The oral NLRP3 inhibitor used in the study has already shown to be effective in clinical trials to treat gout and heart diseases, and it is currently being tested in covid-19 as well.
The researchers are now trying to find out if this NLRP3 inhibitor can be successfully used in melanoma patients who are resistant to checkpoint inhibitors.
“Checkpoint inhibitors increase the efficiency of the immune system to kill tumours, but sometimes tumours become resistant to this treatment,” Marchetti said.
He noted “A big part of cancer research now is to find therapies that can be combined with checkpoint inhibitors to improve their efficiency”.
Johnson and Johnson will soon begin clinical trials of its single-shot Covid-19 vaccine in India, the company told Indian regulators.
In a letter to India’s Central Drugs Standard Control Organization (CDSCO), the U.S. based company said that it would “very shortly apply for permission to conduct clinical bridging trials in India,” reported Indian Express.
The report comes in as many vaccination centres in India suffer a shortage of vaccine supplies as the country of 1.3 billion is battling a second wave of Covid-19 infections that has eclipsed the first.
Delhi CM Arvind Kejriwal called Dr DS Rana, chairman of Sir Gangaram Hospital where as many as 37 doctors have tested Covid positive on Thursday.
Many of those infected are young and most of them were already vaccinated.
“Serving Covid patients at the Sir Ganga Ram Hospital, 37 doctors of the hospital have tested positive for COVID-19. The majority of these corona warriors have mild symptoms. Thirty-two doctors are in home isolation and the rest five are admitted in the hospital,” a hospital source said.
The meeting of CM Kejriwal and Dr Rana will take place at the CM’s residence at 4 pm.
A medical student from Gujarat allegedly committed suicide by jumping into the Narmada canal near Galteshwar village on Wednesday. The medico had recorded a video before killing himself and sent it to his friends stating that he was betrayed in love.
The body of the deceased was found on Thursday in Sanadara siphon of the canal. His bike was also found near the canal with a heavy flow of water.
A case of unnatural death has been registered at the Sevaliya police station.
No fresh COVID cases in the last 7 days in 149 districts. 8 districts have reported no new COVID Cases in the last 14 days; 3 districts in last 21 days and 63 districts in the last 28 days, said Union Health Minister Dr Harsh Vardhan in a meeting of high-level Group of Ministers (GoM) on Covid-19 through video conferencing.
“More than 3 crore vaccinations have been administered to 60 plus beneficiaries, and more than 9.43 crore doses have been given till 9 am today. India has also supported the global community through Vaccine Maitri, under which 6.45 Crore doses of COVID-19 Vaccine have been exported to 85 Countries. 3.58 Crore doses have been supplied to 25 countries under commercial contracts, 1.04 Crore to 44 countries as grants and 1.82 Crore to 39 Countries under COVAX,” he said.
Through the detailed presentation, it was also pointed out that 11 States together contribute to 54% of the total cases & 65% of the total deaths in the country. Disproportionately higher deaths in Maharashtra and Punjab have further increased during the last 14 days (64% of the total deaths in the country). Starting February 2021, a steep increase in cases observed in all the 11 States. Majority of the cases are reported in the younger population (15-44 years of age) and majority of the deaths reported among the elderly population (> 60 years). A high-test positivity rate is seen in Maharashtra (25%) and Chhattisgarh (14%). He highlighted that in many states the proportion of RTPCR-RAT was not satisfactory, while testing capacity in the private sector is underutilized in many states. Also, feedback from the visiting teams indicate laxity in following Covid appropriate behaviour, containment zone activities and increased social gatherings increasing the number of cases.
Dr. V K Paul, Member (Health), NITI Aayog explained the global approach underlying population prioritisation regarding vaccination. The same scientific and evidence-based approach has guided Government of India in its population age groups prioritization for COVID vaccination, he stated. He also detailed efforts to ramp up production of the existing vaccines and also detailed about the potency and timeline of vaccines undergoing clinical trials.
Delhi: Rajiv Gandhi Super Specialty Hospital has suspended all the non-Covid-19 services with immediate effect in the view of Covid-19 case surge, it said in a statement.
The Rajiv Gandhi Hospital has been declared as a Covid-19 dedicated hospital, where only corona patients will be treated.
The hospital had already reserved 500 beds for Covid-19 patients.
Regular OPD services and other services were stated here in January but due to increasing cases of Covid-19, this hospital has been dedicated once again for the Covid-19 treatment.
The cumulative number of COVID19 vaccine doses administered in the country has crossed 9.43 Cr today.
Cumulatively, 9,43,34,262 vaccine doses have been administered through 14,28,500 sessions, as per the provisional report till 7 am today. These include 89,74,511 HCWs who have taken the 1st dose and 54,49,151 HCWs who have taken the 2nd dose, 98,10,164 FLWs (1stdose), 45,43,954 FLWs (2nddose), 3,75,68,0331st dose beneficiaries and 13,61,3672nd dose beneficiaries more than 60 years old and 2,61,03,814 (1st dose) and 5,23,268 (2nd dose) beneficiaries aged 45 to 60.
As on Day-83 of the vaccination drive (8thApril, 2021), 36,91,511 vaccine doses were given. Out of which, 32,85,004 beneficiaries were vaccinated across 49,416 sessions for 1st dose and 4,06,507 beneficiaries received 2nd dose of vaccine.
India continues to report a high surge in Covid cases with a total of 1,31,968 reported in the last 24 hours. Ten States including Maharashtra, Chhattisgarh, Uttar Pradesh, Delhi, Karnataka, Kerala, Madhya Pradesh, Tamil Nadu, Gujarat and Rajasthan have shown a rise in the COVID daily new cases. 83.29% of the new cases are reported from these 10 states.
780 deaths were reported in the last 24 hours.
India’s cumulative recoveries stand at 1,19,13,292 today. The National Recovery Rate is 91.22%.
61,899 recoveries were registered in the last 24 hours.
According to the data given by the government of Delhi, Delhi records 7,437 fresh positive cases and 24 deaths in the last 24 hours. The active cases in Delhi has reached at 23,181, case tally 6,98,005.
Delhi Government directs 115 private hospitals to reserve 50% of their total ICU and ward bed capacity for COVID19 patients